Modulation of CD44 Activity by A6-Peptide

Modulation of CD44 Activity by A6-Peptide

Hyaluronan (HA) is a non-sulfated glycosaminoglycan distributed throughout the extracellular matrix that plays a major role in cell adhesion, migration, and proliferation. CD44, a multifunctional cell surface glycoprotein, is a receptor for HA. In addition, CD44 is known to interact with other receptors and ligands, and to mediate a number of cellular functions as well as disease progression. S...

For Re-Submission to Molecular Cancer Therapeutics A6 peptide Activates CD44 Adhesive Activity, Induces FAK and MEK Phosphorylation and Inhibits the Migration and Metastasis of CD44-Expressing Cells

A6 peptide activates CD44 adhesive activity, induces FAK and MEK phosphorylation, and inhibits the migration and metastasis of CD44-expressing cells.

The A6 peptide (acetyl-KPSSPPEE-amino) has antitumor activity in the absence of significant adverse events in murine tumor models and clinical trials. A6 shares sequence homology with CD44, an adhesion receptor involved in metastasis that is also a marker of cancer stem cells and drug-resistant phenotypes. We investigated the mechanism of action of A6 by examining its effects on CD44 activity, ...

Modulation of hyaluronan production by CD44 positive glioma cells.

This study examines the functional relationship between glioma cell production of hyaluronan (HA), known to play a role in glioma invasion, expression of its CD44 receptor, and glioma cell viability. Production of HA by CD44 positive mouse G26 and human U373 glioma cell lines was evaluated and compared to that of a CD44 positive mouse fibroblast-like L929 cell line. We found that both G26 and U...

O23: Modulation of Pacemaker Channels and Rhythmic Thalamic Activity by Demyelination and Inflammatory Cytokines

The thalamus is a central element for the generation of rhythmic oscillatory activity under physiological and pathophysiological conditions. Especially slow oscillations in the delta and theta frequency band which normally occur during slow-wave sleep are associated with a number of neuropsychiatric conditions if they occur during wakefulness and may be the basis for the generation of character...